![]() ![]() Cytoplasmic influence over cell surface surface components. Transmembrane control of the receptors on normal and tumor cells. Formation of membranes by repeating units. ![]() Green DE, Allmann DW, Bachmann E, Baum H, Kopaczyk K, Korman EF, et al. On the orientation of lipids in chloroplast and cell membranes. Covalently bound ferritin as a membrane marker. The molecular structure and contact relationships of cell membranes. On bimolecular layers of lipoids on the chyromocytes of the blood. The ultrastructure of cell membranes and their derivatives. A contribution to the theory of permeability of thin films. The Fluid Mosaic Model of the structure of cell membranes. Access full text of the manuscript here: See full text (pdf) ReferencesÄ¡. These interactions are important in restraining membrane components and maintaining the unique mosaic organization of cell membranes into functional, dynamic domains. An updated Fluid-Mosaic Membrane Model is described, where more emphasis has been placed on the mosaic nature of cellular membranes where protein and lipid components are more crowded and limited in their movements in the membrane plane by lipid-lipid, protein-protein and lipid-protein interactions as well as cell-matrix, cell-cell and cytoskeletal interactions. In addition, membrane-associated cytoskeletal structures and extracellular matrix also play roles in limiting the mobility and range of motion of membrane components and add new layers of complexity and hierarchy to the original model. More recent information, however, has shown the importance of specialized membrane domains, such as lipid rafts and protein complexes, in describing the macrostructure and dynamics of biological membranes. After more than forty years the model remains relevant for describing the basic nano-scale structures of a variety of biological membranes. Email: Fluid-Mosaic Membrane Model of cell membrane structure was based on thermodynamic principals and the available data on component lateral mobility within the membrane plane. Nicolson, Ph.D, The Institute for Molecular Medicine, P.O. ![]() The Institute for Molecular Medicine, Department of Molecular Pathology, Huntington Beach, CA, USA Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure Discoveries 2013, Oct-Dec 1(1): e3.ÄOI: 10.15190/d.2013.3 Submitted: DecemAccepted: DecemPublished: DecemGO BACK to 2013, Oct-Dec issue Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure. ![]()
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